The JunD Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to JUND. This antibody recognizes Human antigen. The JunD Antibody has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation